Human experimentation with cyberorganics had reached a plateau before they made contact with the Centauri and the other races. Research seemed to be on the verge of a breakthrough in human/computer interface technology. Unfortunately, in the late 2230's the Earth Force grants played out to no success. Project: Lazarus was picked up some time later by a secret government organization. Their group met with success. The application of telepathic therapy was the key element to Lazarus' success. During the operation, the organic brain is hardwired to a computer intelligence which takes over the body's autonomic systems. Soon after the operations, the computer takes complete control of the body. While such agents are very useful in the field, their effectiveness can be limited by those knowing that their internal power plant emits eronium radiation.
(See Also: Conspiracy of Shadows: CyberZombies
Minbari technology can replicate lost limbs to near perfection. Minbari prosthetics are virtually indistinguishable from a real limb, unless a scan is performed. Some members of radical warrior clans choose to have their organic limbs removed and replaced with enhanced artificial limbs. Most such cases have their bionic limb "wired" -- a suicide bomb implant that can be activated by twisting the prosthetic's casing, certain movements, etc.